XBP-1

MSD® XBP-1 Kit For quantitative determination in human, mouse, and rat whole cell lysate samples Alzheimer’s Disease BioProcess Cardiac Cell Signaling Clinical Immunology Cytokines Growth Factors Hypoxia Immunogenicity Inflammation Metabolic Oncology Toxicology Vascular Catalog Numbers XBP-1 Kit Kit Size Catalog # 1 plate K150QKD-1 5 plates K150QKD-2 25 plates K150QKD-4 1. XBP-1 2. BSA blocked 3. BSA blocked 4. BSA blocked X-box binding protein 1 (XBP-1) is a basic-region, leucine zipper type transcription factor that belongs to the CREB/ATF family and mediates one of the three arms of unfolded protein response (UPR) adaptation to endoplasmic reticulum (ER) stressors. The accumulation of unfolded or misfolded proteins in the ER is a threat to cell survival and results in a condition known as ER-stress.1,2 To overcome this stress, the ER initiates specific signaling pathways encompassed by the ER stress response.3 Among these are translational attenuation, upregulation of ER chaperone proteins and proteins that facilitate folding, activation of NFkB signaling, and, as a last resort, the induction of apoptosis.4-6 Under basal conditions, XBP-1 is ubiquitously expressed as a 33 kDa XBP-1u isoform. The initiation of ER stress activates the endonuclease activity of the transmembrane kinase and endoribonuclease inositol-requiring enzyme-1 (IRE-1) in an unconventional cleavage and re-ligation reaction producing an active 52 kDa splice-variant form of XBP-1 known as XBP-1s....