Part Number
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SC-31155 |
Manufacturer
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Santa Cruz Biotechnology |
Description
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EGFR (N-20) |
Published
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Jul 16, 2009 |
Detailed Description
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SANTA CRUZ BIOTECHNOLOGY, INC.
www.DataSheet4U.com
EGFR (N-20): sc-31155
The Power to Question
BACKGROUND
The EGF rece...
|
Datasheet
|
SC-31155
|
Overview
SANTA CRUZ BIOTECHNOLOGY, INC.
www.
DataSheet4U.
com
EGFR (N-20): sc-31155
The Power to Question
BACKGROUND
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas.
Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding.
Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights.
EGFR binds several ligands, including epidermal growth factor (EGF), trans...
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