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SC-7415

ETC
Part Number SC-7415
Manufacturer ETC
Description Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors
Published Apr 8, 2005
Detailed Description Santa Cruz Biotechnology, Inc. SANTA CRUZ G α 16 (C-18): sc-7415 BIOTECHNOLOGY BACKGROUND Heterotrimeric G proteins f...
Datasheet PDF File SC-7415 PDF File

SC-7415
SC-7415

Overview
Santa Cruz Biotechnology, Inc.
SANTA CRUZ G α 16 (C-18): sc-7415 BIOTECHNOLOGY BACKGROUND Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1).
Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.
e.
, adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous.
In mammals, G protein a, b and g polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5).
Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors.
Four distinct classes of Gα subunits have been identified; these include Gs, Gi, unc and Gα 12/13 (3,4).
The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Gα i-1, Gα...


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